"twister is the fully decentralized P2P microblogging platform leveraging from the free software implementations of Bitcoin and BitTorrent protocols."

vmail is a Vim interface to Gmail.

E-mail notification is a good idea.

"PyBrain is a modular Machine Learning Library for Python. It's goal is to offer flexible, easy-to-use yet still powerful algorithms for Machine Learning Tasks and a variety of predefined environments to test and compare your algorithms. "

Spyse is a software framework for building multi-agent systems. It allows Python developers to build distributed intelligent systems of multiple cooperative agents based on FIPA, OWL, SOA and many others. Spyse is designed for ease-of-use and fun.